专利名称：A METHOD OF IMPROVING EFFICACY OF
BIOLOGICAL RESPONSE-MODIFYINGPROTEINS AND THE EXEMPLARY MUTEINS
发明人：CHUNG, YONG-HOON,LEE, HAK-SUP,YI, KI-WAN,HEO, YOUN-HWA,KIM, JAE-YOUN
申请号：EP04735139申请日：20040527公开号：EP1668030A4公开日：20060614
摘要：Disclosed is a protein variant which substitutes valine for phenylalanine residuein a binding domain having a biological response-modifying function by binding to areceptor, ligand or substrate. Also, the present invention discloses a DNA encoding theprotein variant, a recombinant expression vector to which the DNA is operably linked, ahost cell transformed or transfected with the recombinant expression vector, and amethod of preparing the protein variant comprising cultivating the host cell and isolatingthe protein variant from the resulting culture. Further, the present invention discloses apharmaceutical composition comprising the protein variant and a pharmaceuticallyacceptable carrier.
申请人：MEDEXGEN CO., LTD.
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