专利名称：Modulators of pharmacological agents发明人：Sullenger, Bruce A.,Rusconi, Christopher申请号：EP09156205.8申请日：20020528公开号：EP2070939B1公开日：20140402
摘要：The biological activity of nucleic acid ligand is regulated (i.e. enhanced orinhibited) in vivo to produce a desired biological effect. This is accomplished through theadministration of a pharmaceutical composition comprising a modulator that changes thebinding of the nucleic acid ligand for its target or that degrades or otherwise cleaves,metabolizes or breaks down the nucleic acid ligand while the ligand is still exerting itseffect. Modulators of the present invention can be administered in real time as neededbased on various factors including the progress of the patient, as well as the physician'sdiscretion in how to achieve optimal therapy. Thus, this invention provides for the firsttime a regulatable therapeutic regime in the course of nucleic acid ligand therapy.
申请人：UNIV DUKE
地址：US
国籍：US
代理机构：HOFFMANN EITLE
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