Functional heavy chain antibodies, fragments there

专利名称：Functional heavy chain antibodies, fragments

thereof, library thereof and methods ofproduction thereof

发明人：Serge Muyldermans,Viet Khong Nguyen申请号：US12498835申请日：20090707公开号：US09156905B2公开日：20151013

摘要：The present invention relates to functional heavy chain antibodies, functionalsingle domain heavy chain antibodies, functional VH domains, or functional fragmentsthereof comprising an amino acid which is neither a charged amino acid nor a C at position45, and comprising an amino acid at position 103 independently chosen from the groupconsisting of R, G, K, S, Q, L, and P, and optionally an amino acid at position 108

independently chosen from the group consisting of Q, L and R, said positions determinedaccording to the Kabat numbering.

申请人：Serge Muyldermans,Viet Khong Nguyen

地址：Hoelaart BE,Hanoi VN

国籍：BE,VN

代理机构：Wolf, Greenfield & Sacks, P.C.

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