STEROIDAL DERIVATIVES

专利名称：STEROIDAL DERIVATIVES发明人：LIAO, Shutsung,SONG, Ching申请号：EP02704407.2申请日：20020207公开号：EP1385868A2公开日：20040204

摘要：The compound of formula (1), wherein each R1, R2, R4, R4', R7, R11, R12, R15,R16, R17', independently, it is hydrogen, hydroxyl, amino, carboxyl, it is oxygen containing,halation, sulfonic acid,-O- sulfonic acid, or that alkyl-NH- for being optionally inserted,-N(alkyl)-,-O,-S,-SO,-SO2,-O-SO2,-SO2-O-,-SO3-O-,-CO,-CO-O-,-O-CO-,-CO-NH-,-CON (alkyl)-,-NH-CO-, or-N (alkyl-CO-, optionally further by hydroxyl, halation, amino, carboxyl,sulfonic acid, or-O- sulfonic acid replaces; R3 is X-Y-, and wherein X is hydrogen, amino,carboxyl, halation, sulfonic acid ,-O- sulfonic acid or alkyl; Y is-S ,-NH- ,-N (alkyl)-,-SO ,-SO2,-O-SO2- ,-SO2-O- ,-SO3-O- ,-CO ,-CO-O- ,-O-CO- ,-CON (alkyl)-CO; R5 and R6 is together-O; Or R5 and R6 is together the double bond between C-5 and C-6, R7 is oxygen

containing; Each R8, R9, R10, R13 and R14 are independently hydrogen, alkyl, halogenatedalkyl, hydroxyalkyl, alkoxy, hydroxyl or amino; N is 0,1 or 2. It also discloses a kind of forhandling hypocholesterolemia and a kind of method for the method for an anti-depressant screening of LXR by management above compound, one pharmaceuticalcomposition, include at least one above-mentioned compound, and an antibody, to 5 α, 6α-epoxycholesterol-3- sulfate or 7 ketocholesterol-3- sulfate.

申请人：The University of Chicago

地址：50 South Ellis Avenue,Suite 405 Chicago, IL 60637 US

国籍：US

代理机构：Brandenburg, Thomas, Dr.

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