专利名称：Treatment for rheumatoid arthritis发明人：Godwood, Alex,Magrini, Fabio申请号：AU2012322991申请日：20121010公开号：AU2012322991A1公开日：20140327
摘要：Treatment of rheumatoid arthritis (RA) to provide clinical benefit in patients,including decrease in DAS28-CRP by more than 1.2 and/or improvement determined byACR20, ACR50 or ACR70, comprising administering therapeutic antibody mavrilimumab orother inhibitor targeted to Tyr-Leu-Asp-Phe-Gln motif of granulocyte/macrophagecolony stimulating factor receptor alpha (GM-CSFRα). Use of GM-CSFRα inhibitors such asmavrilimumab to enhance clinical benefit in RA patients receiving stable dose of DMARDs,particularly methotrexate.
申请人：MedImmune Limited
代理人：Phillips Ormonde Fitzpatrick
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