Process for the purification of alpha-bisabolol

专利名称：Process for the purification of alpha-bisabolol

发明人：BRUNKE, ERNST-JOACHIM, DR.,KOESTER,

FRANK-HINRICH, DR.

申请号：EP86115246.0申请日：19861104公开号：EP0253922A1公开日：19880127

摘要：alpha -Bisablol has distinct odour-fixing properties, which makes it very difficultto separate off attendant mixtures of unpleasant odour from a crude product (which maybe of natural or synthetic origin). The conventional purification operations such asdistillation, adsorption on activated carbon, or the like, fail, so that n the past relativelycomplicated chemical treatments were required. The purification process now proposedconsists in filtering a solution of crude alpha -bisabolol in an inert solvent having a boilingpoint of between 40 and 200 DEG C, preferably 60 - 150 DEG C, through an exchangerresin, then removing the solvent and, if desired, subjecting it to further purificationoperations. The solvent is advantageously an aliphatic alcohol having up to 6 carbonatoms, preferably isopropanol, which is used in an amount of 10 to 1000 % by weight,preferably 50 - 200 % by weight, relative to the crude alpha -bisabolol. The preferredexchanger resin is a highly polymeric crosslinked polycondensation or polymerisationresin whose active groups are either acidic groups, preferably sulphonic acid, carboxylateor phenol groups or basic groups, preferably mono- or polyalkylated amino groups, itbeing sufficient to use an amount of 5 - 100 % by weight, preferably 10 - 50 % by weight

of resin, reactive to the crude alpha -bisabolol. This purification process has surprisinglygood effectiveness and is distinguished, compared with chemical treatments, by extremesimplicity, low expenditure on equipment, work and auxiliaries and very lowenvironmental pollution.

申请人：DRAGOCO GERBERDING & CO. GMBH

地址：Dragocostrasse 1 D-37603 Holzminden DE

国籍：DE

代理机构：Eikenberg & Brümmerstedt Patentanwälte

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